Table 2.
Baseline characteristics by geographic region
| North America | Western Europe/Israel | South America | Eastern Europe/Russia | Japan | Asia | Australia/South Africa | Overall | |
|---|---|---|---|---|---|---|---|---|
| ( n = 832) | ( n = 412) | ( n = 196) | ( n = 195) | ( n = 191) | ( n = 169) | ( n = 84) | ( N = 2,079) | |
| Study population with mild AD | 547 (66%) | 265 (64%) | 114 (58%) | 106 (54%) | 132 (69%) | 71 (42%) | 57 (68%) | 1,292 (62%) |
| Mean (SD) age (years) | 75.0 (8.1) | 71.6 (7.7) | 74.6 (8.0) | 70.9 (7.7) | 73.1 (7.7) | 72.2 (7.7) | 73.0 (7.1) | 73.4 (8.0) |
| Mean (SD) education (years) | 14.0 (3.1) | 11. 2 (4.2) | 9.1 (4.5) | 11.8 (3.7) | 11. 8 (2.8) | 9.6 (4.7) | 12.2 (3.4) | 12.1 (4.1) |
| Male | 381 (45.8%) | 205 (49.8%) | 66 (33.7%) | 70 (35.9%) | 73 (38.2%) | 68 (40.2%) | 38 (45.2%) | 901 (43.3%) |
| AChEI and/or memantine | 736 (88.5%) | 387 (93.9%) | 167 (85.2%) | 145 (74.4%) | 173 (90.6%) | 139 (82.2%) | 66 (78.6%) | 1,813 (87.2%) |
| APOE ε4 carriers | 481 (63.0%) | 218 (65.7%) | 96 (51.1%) | 90 (51.4%) | 98 (53.0%) | 39 (42.4%) | 51 (61.4%) | 1,073 (59.0%) |
| Mean (SD) baseline scores | ||||||||
| ADAS-cog11 | 21.81 (9.01) | 22.97 (9.18) | 24.20 (8.75) | 27.69 (11.13) | 21.37 (6.80) | 24.72 (7.72) | 21.89 (9.51) | 23.02 (9.16) |
| ADCS-ADL | 62.68 (11.66) | 59.34 (13.62) | 53.72 (14.17) | 49.51 (16.91) | 60.45 (11.16) | 57.02 (4.80) | 59.62 (13.04) | 59.16 (13.76) |
| MMSE | 21.08 (3.67) | 21.10 (3.56) | 20.37 (3.07) | 20.19 (3.15) | 20.75 (3.10) | 19.49 (3.57) | 20.86 (3.49) | 20.77 (3.51) |
| CDR-SB | 5.08 (2.48) | 5.41 (2.70) | 6.19 (2.74) | 7.16 (3.34) | 4.95 (2.66) | 4.64 (2.53) | 5.38 (2.32) | 5.41 (2.74) |
| NPI | 9.21 (10.94) | 11.03 (11.73) | 12.34 (12.82) | 11.24 (11.86) | 6.70 (8.69) | 7.62 (8.68) | 12.13 (10.80) | 9.81 (11.13) |
Data presented as number (%) or mean (standard deviation). AChEI, acetylcholinesterase inhibitor; AD, Alzheimer’s disease; ADAS-cog11, 11-item Alzheimer’s disease Assessment Scale – cognitive subscale; ADCS-ADL, Alzheimer’s disease Cooperative Study – Activities of Daily Living; APOE, apolipoprotein E; CDR-SB, Clinical Dementia Rating Scale sum of boxes; MMSE, Mini-Mental State Examination; NPI, Neuropsychiatric Inventory; SD, standard deviation.