Table 3.
Observed change from baseline to 76/80 weeks by region for outcome measure scores
| North America | Western Europe/Israel | South America | Eastern Europe/Russia | Japan | Asia | Australia/South Africa | Overall | |
|---|---|---|---|---|---|---|---|---|
| ( n = 832) | ( n = 412) | ( n = 196) | ( n = 195) | ( n = 191) | ( n = 169) | ( n = 84) | ( N = 2,079) | |
| ADAS-cog11 | ||||||||
| 6 months | 1.62 (5.66) | 1.99 (6.12) | 0.99 (6.51) | 3.06 (7.23) | 0.68 (5.04) | 0.21 (6.06) | 1.64 (5.97) | 1.55 (6.00) |
| 12 months | 3.88 (7.40) | 4.92 (7.76) | 3.23 (7.28) | 6.53 (9.11) | 3.18 (6.57) | 1.49 (7.04) | 5.44 (8.39) | 4.07 (7.62) |
| 18 months | 6.04 (9.44) | 7.46 (9.68) | 4.76 (8.41) | 10.95 (10.77) | 4.41 (7.99) | 3.52 (7.98) | 7.3 (11.54) | 6.23 (9.48) |
| ADCS-ADL | ||||||||
| 6 months | −3.2 (7.45) | −3.41 (8.90) | −1.17 (9.09) | −2.07 (8.63) | −2.03 (6.78) | −2.05 (7.86) | −2.29 (9.82) | −2.71 (8.12) |
| 12 months | −6.26 (10.01) | −6.08 (11.08) | −3.7 (9.79) | −6.39 (12.80) | −4.13 (8.76) | −4.71 (10.02) | −6.18 (13.12) | −5.66 (10.51) |
| 18 months | −9.16 (12.13) | −10.84 (13.44) | −5.57 (12.78) | −11.51 (14.16) | −5.94 (9.39) | −7.85 (9.75) | −9.00 (14.89) | −8.95 (12.48) |
| MMSE | ||||||||
| 6 months | – | – | – | – | – | – | – | – |
| 12 months | −2.29 (3.56) | −2.14 (3.84) | −1.39 (3.49) | −3.48 (4.73) | −1.79 (3.34) | −2.22 (2.92) | −2.45 (3.79) | −2.21 (3.68) |
| 18 months | −3.39 (4.59) | −3.66 (4.70) | −2.52 (4.18) | −5.28 (5.95) | −2.78 (4.13) | −2.93 (4.06) | −3.45 (4.73) | −3.38 (4.60) |
| CDR-SB | ||||||||
| 6 months | 5.77 (3.06) | 6.19 (3.24) | 6.75 (3.18) | 7.59 (3.82) | 5.64 (3.31) | 5.12 (2.74) | 6.25 (3.11) | 6.05 (3.24) |
| 12 months | 6.47 (3.46) | 6.77 (3.67) | 7.15 (3.47) | 8.74 (4.09) | 6.32 (3.71) | 5.91 (3.24) | 7.45 (3.86) | 6.75 (3.64) |
| 18 months | 6.98 (3.91) | 7.23 (3.98) | 7.09 (3.59) | 9.72 (4.66) | 6.32 (3.92) | 6.25 (3.25) | 7.90 (4.32) | 7.10 (3.96) |
| NPI | ||||||||
| 6 months | 0.73 (9.52) | 0.87 (10.43) | 0.00 (11.04) | 0.09 (10.79) | −0.05 (6.79) | 0.71 (9.47) | 0.68 (10.73) | 0.55 (9.77) |
| 12 months | 1.57 (11.15) | 0.63 (11.25) | 0.81 (13.48) | 0.82 (10.88) | 2.04 (9.09) | 2.02 (12.76) | 2.44 (11.46) | 1.37 (11.30) |
| 18 months | 2.86 (13.36) | 2.97 (13.98) | −1.80 (14.08) | 2.30 (12.57) | 2.41 (8.95) | 1.83 (10.00) | 5.29 (14.11) | 2.47 (13.11) |
Data presented as mean (standard deviation). ADAS-cog11, 11-item Alzheimer’s disease Assessment Scale – cognitive subscale; ADCS-ADL, Alzheimer’s disease Cooperative Study – Activities of Daily Living; CDR-SB, Clinical Dementia Rating Scale sum of boxes; MMSE, Mini-Mental State Examination; NPI, Neuropsychiatric Inventory.