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PY firing rate for in vivo and simulated data. The firing rate of cell is in the output layer of the motor cortex is antidromically modulated by STN DBS. The modeled PY cells reproduce the same trends of differential modulation as found from recordings in the hemi-parkinsonian rodent model. In both the observed data and model data, increasing stimulation frequency produced increases in firing rates (post-hoc LSD: *p < 0.05, **p < 0.01).
