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. 2015 Jun 26;9:78. doi: 10.3389/fncom.2015.00078

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Copyright © 2015 Summerson, Aazhang and Kemere.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Entropy of ISIs for in vivo and simulated data. The activity produced by the computational model (n = 50, blue) follows the same trends as the in vivo data (n = 48, red). Spike trains are more bursty in the parkinsonian state, but the bursiness decreases with increasing stimulation frequency (post-hoc LSD: ^*p < 0.05). 130 Hz regular and irregular DBS both restored the ISI entropy to the level of the intact hemisphere, meaning the ISI entropy was not significantly different (n.s.; post-hoc LSD: p > 0.05).