Table 1.
Neurological deficit score distribution and median scores at various reperfusion time points following 1 h of middle cerebral artery occlusion (MCAO) in male C57BL/6J (wild-type, WT) treated intravenously with RPMI (Vehicle) or 5 million IL10+ B-cells 24 h after MCAO.
| Experimental Groups | Distribution Of Neurological Deficit Scores During Reperfusion |
||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 h | 24 h | 48 h | 72 h | 96 h | |||||||||||||||||||||
| 0 | 1 | 2 | 3 | 4 | 0 | 1 | 2 | 3 | 4 | 0 | 1 | 2 | 3 | 4 | 0 | 1 | 2 | 3 | 4 | 0 | 1 | 2 | 3 | 4 | |
| WT+RPMI (n=28) | 0 | 0 | 19 | 9 | 0 | 0 | 13 | 15 | 0 | 0 | 0 | 19 | 8 | 1 | 0 | 0 | 19 | 6 | 3 | 0 | 5 | 14 | 5 | 4 | 0 |
| WT+IL10+ B Cells (n=30) | 0 | 0 | 17 | 13 | 0 | 0 | 13 | 14 | 3 | 0 | 0 | 20 | 7 | 3 | 0 | 4 | 20 | 5 | 1 | 0 | 13 | 13 | 2 | 2 | 0 |
| Experimental Groups | Median Neurological Deficit Scores During Reperfusion |
||||
|---|---|---|---|---|---|
| 1 h (P=0.4268) | 24 h (P=0.5711) | 48 h (P=0.8513) | 72 h (P=0.0830) | 96 h (P=0.0235) | |
| WT+RPMI (n=28) | 2 | 2 | 1 | 1 | 1 |
| WT+IL10+ B Cells (n=30) | 2 | 2 | 1 | 1 | 1# |
#
p<0.01 compared to WT + RPMI