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Small molecule inhibitor of PTP1B MSI-1436 exerted opposite regulatory effects on BRK and SRC. T47D breast cancer cell lines were treated with a specific PTP1B inhibitor, MSI-1436, for 4 h at the indicated concentration. Phosphorylation of IRS-1, BRK, and SRC was compared after treatment. The activation status of SRC was quantified by ImageJ and normalized to total protein levels.
