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Inhibition of hTNF and mTNF binding to mTNFR1 by CrmE and CrmC. SPR competition experiment of 30 nm mTNF (A) and hTNF (B) binding to mTNFR1-coupled biosensor chips with increasing amounts of soluble CrmC (■) and CrmE (●). The percentage of binding refers to binding in the absence of soluble vTNFRs. RU, response units.
