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PiC inhibition blocks acceleration of Ca2+ uptake and matrix Ca2+ buffering. 10 μm (blue), but not 1 μm (red), mersalyl inhibited the Pi effect on mitochondrial Ca2+ uptake (A) and buffering (B). C, ΔΨm was partially depolarized in the presence of 10 μm mersalyl, which may account for the somewhat slower initial Pi-independent Ca2+ uptake kinetics.
