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FBXO32-mediated c-Myc degradation is independent of the phosphorylation of c-Myc at Thr-58 and Ser-62. A, co-transfection of HA-FBXO32 causes protein degradation of wild-type c-Myc as well as c-Myc mutants T58A, S62S, and T58A/S62A. B, co-transfection of HA-FBXO32 causes protein degradation of wild-type c-Myc as well as c-Myc mutants P57S and S62E. C, co-transfection of HA-FBXO32 causes protein degradation of wild-type c-Myc as well as c-Myc mutants S71A, Y74A, T358A, and S373A.
