FIGURE 1.

Phlpp1 regulates bone mass. A, femur lengths from 4-week-old animals. B, percent change in bone volume per total volume (BV/TV); (C) trabecular number (Tb. N); (D) trabecular thickness (Tb. Th); (E) trabecular spacing (Tb. Sp); and (F) connective density (Conn. D) of distal femurs from 8-week-old WT (n = 3) and Phlpp1^−/− (n = 4) mice were determined by micro-computed tomography. *, p < 0.05 compared with control. G and H, microCT reconstructions are shown of cancellous bone and secondary spongiosa from distal femurs of 8-week-old WT and Phlpp1^−/− mice.