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Working Model. Phlpp1 represses Akt2 activity in chondrocytes leading to increased FoxO1-mediated repression of Fgf18 expression. In the absence of Phlpp1, increased Akt activity diminishes FoxO1 levels and increases Fgf18 expression, which stimulates Erk1/2 phosphorylation and chondrocyte proliferation.
