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. 2015 May 7;290(26):16330–16342. doi: 10.1074/jbc.M115.661405

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© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 6. — Sensitivity of BAFF-APRIL heteromers of defined stoichiometries to BAFF and APRIL inhibitors. BCMA:Fas and TACI:Fas reporter cell lines were treated with lethal doses (except for BBA, BAB, and ABB on BCMA:Fas cells; dose in ng/ml indicated in parentheses) of the indicated single-chain or conventional BAFF and/or APRIL-containing ligands, in the presence or absence of titrated amounts of hTACI-Ig (atacicept) or anti-BAFF mAb (belimumab). Cell survival was monitored with a cell viability assay. One experiment out of two with similar results is shown.