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. Author manuscript; available in PMC: 2015 Nov 28.
Published in final edited form as: Nature. 2015 Mar 23;521(7553):537–540. doi: 10.1038/nature14216

Extended Data Figure 10.

Extended Data Figure 10

Related to Figure 4

a, Frequency distribution (left) and scatter plot (right) of total distances travelled by uncapped telomeres in control or Mad2l2 knockdown cells. b, qRT-PCR analysis of Mad2l2 expression levels and Western blot analysis of 53BP1 proteins levels in TRF2ts cells used in the experiments shown in a and c (Error bars: ± s.d.). c, Distance travelled by 10 representative uncapped telomeres for each condition. While multiple uncapped telomeres in 53BP1-depleted cells have reduced mobility, this is not seen for uncapped telomeres in MAD2L2-depleted cells. d, Model of the role of MAD2L2 in promoting NHEJ.