Fig 1. The effects of combining As3+ and As4S4 on the growth of NB4 and primary APL cells.
(A) The effects of As3+ on cell viability. (B) The effects of As4S4 on cell viability. (C&D) The combined effects of As3+ and As4S4 on cell viability. (E) CI of concurrent treatment with As3+ and As4S4 in NB4 cells. (F) CI in primary APL cells. CI<1.0 indicated a synergistic effect. The viability of NB4 and primary APL cells were determined by WST-1 cell proliferation assay kit after 48 h of treatment. Error bars represent the S.D. from the mean of three separate experiments. **P<0.01 compared with the control. ##P<0.01 compared with As3+ and As4S4 combination treated cells.