Fig 7. As4S4 acts synergistically with As3+ to affect NB4 and primary APL cell differentiation.
(A) The effects of As4S4 on CD11b expression in NB4 cells. (B) The effects of As4S4 on As3+-induced differentiation in NB4 cells. (C) The effects of As4S4 on As3+-induced differentiation in primary APL cells. (D) The percentage of FITC-CD11b-positive primary APL cells. (E) Western-blot analysis of PML-RARα expression in NB4 and primary APL cells. The figures show a representative experiment of three independent experiments. **P<0.01 compared with 0.2 μM As3+ and 0.2 μM As4S4 combination treated cells.