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. 2015 Jun 26;5:11611. doi: 10.1038/srep11611

Figure 7. Effects of EE and IE in combination with abstinence on the recovery from ketamine-induced renal toxicity.

Figure 7

(A) The kidney and body weight ratio of the Ketamine SA + IE, Ketamine SA + EE groups and the corresponding control (Saline + IE, Saline + EE) groups (B–E). Representative images of H&E staining for a Saline + IE, a Ketamine SA + IE, a Saline + EE, and a Ketamine SA + EE rat. Arrow represents tubular edema. (F) KIM-1 levels of Ketamine SA + IE, Ketamine SA + EE groups and the corresponding control (Saline + IE, Saline + EE) groups (G–J). Representive images of IHC staining for a Saline + IE, a Ketamine SA + IE, a Saline + EE, and a Ketamine SA + EE rat. Arrow represents a cell with positive expression of KIM-1. (K) KIM-1 levels of Ketamine SA + IE, Ketamine SA + EE groups and the corresponding control (Saline + IE, Saline + EE) groups. (I) TUNEL + cells (%) of Ketamine SA + IE, Ketamine SA + EE groups and the corresponding control (Saline + IE, Saline + EE) groups (L, M, N, O) Representive images of TUNEL staining for a Saline + IE, a Ketamine SA + IE, a Saline + EE, and a Ketamine SA + EE rat. Arrow represents an apoptotic cell. Data are expressed as mean ± SEM. KIM-1: Kidney Injury Molecule 1; TUNEL: Terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling staining; IE: isolated environment; EE: enriched environment; KW: kidney weight; BW: body weight.