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. 2015 Jun 26;5:11596. doi: 10.1038/srep11596

Figure 3. The effects of ebselen and antibiotics (linezolid, mupirocin, vancomycin and rifampicin) on established biofilms of S. aureus (a) or S. epidermidis(b).

Figure 3

The established biofilms were treated with control antibiotics or ebselen and stained with crystal violet. Optical density of dissolved crystal violet was measured using a spectrophotometer. Values are the mean of triplicate samples with the standard deviation bars. P values of (*,#P ≤ 0.05) are considered as significant. Ebselen was compared to controls (*) and to antibiotics (#). Detailed P values are listed: S. aureus (a): Control vs linezolid, 0.0214; Control vs mupirocin, 0.0001; Control vs vancomycin, 0.004; Control vs rifampicin, 0.0001; Control vs ebselen, 0.0001; linezolid vs ebselen, 0.0014; mupirocin vs ebselen, 0.0004; vancomycin vs ebselen, 0.003; rifampicin vs ebselen, 0.0047. S. epidermidis (b): Control vs linezolid, 0.0036; Control vs mupirocin, 0.0008; Control vs vancomycin, 0.0011; Control vs rifampicin, 0.0004; Control vs ebselen, 0.0004; linezolid vs ebselen, 0.0033; mupirocin vs ebselen, 0.0052; vancomycin vs ebselen, 0.0040; rifampicin vs ebselen, n.s (not significant).