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. 2015 Jun 26;5:11633. doi: 10.1038/srep11633

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Copyright © 2015, Macmillan Publishers Limited

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(A) Cancer cells acquire cancer-specific HOT regions. DNase-seq profiles are shown surrounding the oncogenes BRCA2, MYC, CANT1 and FAS in breast cancer, hepatocellular carcinoma, prostate cancer, and malignant melanoma, respectively, as well as in their healthy counterparts. Cancer-specific HOT regions surround the TSS of the oncogene. (B) Colorectal cancer-specific CCAT1-L lncRNA regulates long-range chromatin interactions at the MYC locus. DNase-seq profiles are shown within the region between CCAT1 and MYC; the HOT regions are found surrounding these two genes. (C) Tal1 binding is observed in HOT regions in K562 cells. The DNase-seq profile and ChIP-seq binding profile of TAL1 are coloured grey and yellow, respectively. (D) Two breakpoints of the fusion gene BCAS3-BCAS4 are found in breast cancer-specific HOT regions. DNase-seq profiles surrounding these two breakpoints in MCF7 cell are shown. (E) Large HOT regions are observed at the site of focal amplification in breast cancer. See also Fig. S3 and Table S1.