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Lack of TFPI increases the susceptibility to thrombosis of Par4−/− mice in a TF-induced pulmonary embolism model. The time to respiratory arrest after injection of TF was measured. Shown is the percentage of survivors over time. The fraction of surviving Par4−/− mice is greater than surviving Tfpi−/−:Par4−/− mice (P = .0363), and the fraction of both Par4−/− and Tfpi−/−:Par4−/− surviving mice is greater than wild-type mice (P < .0001 and P = .0319, respectively).
