. 2014 Nov 25;211(10):1550–1559. doi: 10.1093/infdis/jiu658

Table 5.

Unadjusted and Multivariable Associations of Respiratory Syncytial Virus (RSV) Genomic Loads with Bronchiolitis Outcomes, According to RSV Subtype

Outcome, RSV Genomic Load Tertile^a	RSV-A				RSV-B
	Unadjusted Model^b		Adjusted Model^c		Unadjusted Model^b		Adjusted Model^c
	OR (95% CI)	P Value	OR (95% CI)	P Value	OR (95% CI)	P Value	OR (95% CI)	P Value
LOS ≥3 d
Low	Reference		Reference		Reference		Reference
Intermediate	1.33 (1.02–1.73)	.04	1.32 (.97–1.80)	.08	1.54 (1.14–2.07)	.004	1.57 (1.09–2.26)	.02
High	1.41 (1.05–1.91)	.03	1.47 (1.02–2.10)	.04	1.77 (1.24–2.52)	.002	1.85 (1.32–2.58)	<.001
Intensive care use
Low	Reference		Reference		Reference		Reference
Intermediate	0.93 (.73–1.19)	.57	0.89 (.66–1.20)	.44	1.31 (.82–2.12)	.26	1.39 (.82–2.36)	.22
High	1.15 (.90–1.45)	.26	1.09 (.81–1.47)	.57	2.13 (1.16–3.93)	.02	2.12 (1.05–4.27)	.04

Abbreviations: CI, confidence interval; LOS, length of hospital stay; OR, odds ratio.

^a Threshold cycle tertiles for RSV genomic loads were defined as follows: low, ≥24.3; intermediate, 20.8–24.2; and high, <20.8.

^b Unadjusted model controlling for clustering of patients within the sites, using the generalized estimating equations.

^c Multivariable model controlling for 10 patient-level variables (age, sex, race/ethnicity, gestational age, maternal smoking during pregnancy, history of wheezing, history of eczema, comorbid medical disorder, duration of difficulty breathing before hospitalization, and viral coinfection status [RSV plus rhinovirus and RSV plus nonrhinovirus pathogens]) and clustering of patients within the sites.