Table 6.
Unadjusted and Multivariable Associations of Respiratory Syncytial Virus (RSV) Genomic Loads With Bronchiolitis Outcomes in Children With RSV Monoinfection
| Outcome, RSV Genomic Load Tertile | Unadjusted Modela |
Adjusted Modelb |
||
|---|---|---|---|---|
| OR (95% CI) | P Value | OR (95% CI) | P Value | |
| LOS ≥3 d | ||||
| Low | Reference | Reference | ||
| Intermediate | 1.53 (1.17–1.99) | .002 | 1.43 (1.06–1.95) | .02 |
| High | 1.76 (1.36–2.28) | <.001 | 1.70 (1.30–2.23) | <.001 |
| Intensive care use | ||||
| Low | Reference | Reference | ||
| Intermediate | 1.37 (1.03–1.82) | .03 | 1.24 (.93–1.65) | .15 |
| High | 1.87 (1.37–2.56) | <.001 | 1.69 (1.21–2.36) | .002 |
Abbreviations: CI, confidence interval; LOS, length of hospital stay; OR, odds ratio.
a Threshold cycle tertiles for RSV genomic loads were defined as follows: low, ≥24.3; intermediate, 20.8–24.2; and high, <20.8.
b Unadjusted model controlling for clustering of patients within the sites, using the generalized estimating equations.
c Multivariable model controlling for 9 patient-level variables (age, sex, race/ethnicity, gestational age, maternal smoking during pregnancy, history of wheezing, history of eczema, comorbid medical disorder, and duration of difficulty breathing before hospitalization) and clustering of patients within the sites.