Figure 2.

(A) Average glycemic control (CTL) as measured by percent glycation of hemoglobin chain A1c after 8 weeks of study in aged mice (n = 8–10/group). Only HT mice showed significantly better glucose CTL compared with CTL mice (p = .02) and geranylgeranylacetone (GGA; p = .006). Unlike letters denotes significance between groups. (B) Fasting insulin concentrations at study end. Both GGA and HT mice had significantly lower insulin levels compared with CTL mice (p = .03 for both; n = 6–9/group) which suggest improved insulin sensitivity. Unlike letters denotes significance between groups.