Skip to main content
. 2014 Aug 14;70(7):800–808. doi: 10.1093/gerona/glu119

Figure 3.

Figure 3.

(A) Basal activated insulin receptor substrate 1 (IRS1) levels in skeletal muscle of aged mice after 8 weeks of study. The HT had significantly lower activation (p = .03; n = 8/group) compared with control (CTL). (B) Basal activated Akt levels in skeletal muscle of aged mice at study end (p = .13; n = 8/group). The HT mice had 40% lower levels than CTL. (C) Total IRS1 levels in skeletal muscle of aged mice indicate HT mice have greater capacity for insulin receptor activation with more than double the levels seen in CTL mice (p = .02; n = 8/group). (D) Total Akt levels in skeletal muscle of aged HT mice are more than twice that of CTL and geranylgeranylacetone mice at study end (p = .04 and .02, respectively; n = 8/group).