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. Author manuscript; available in PMC: 2015 Sep 1.
Published in final edited form as: Dev Biol. 2014 Jun 24;393(1):109–123. doi: 10.1016/j.ydbio.2014.06.014

Fig. 6.

Fig. 6

Hypothesis: “Early” determinants are required for SM specification through serotonin accumulation in epithelial cells. (A) Schematic depiction of serotonin accumulation in the epithelial layer of the blastocoel roof before the onset of gastrulation. Transversal sections of 32- and 128-cell embryos (plane indicated in light blue) and sagittal (animal-vegetal) section of stage 9 blastula embryo. bc, blastocoel; d, dorsal; v, ventral. Redrawn from (Beyer et al., 2012a; Vandenberg and Levin, 2010b). (B) Apical enrichment of serotonin through Rab11/Kif16b/microtubule (MT) mediated exocytosis, re-uptake through SERT and re-packaging into vesicles through V-MAT. (C) Epithelialization of the outer layer of the blastula. For details see text.