. 2015 Jun 26;5:11846. doi: 10.1038/srep11846

Table 2. Association of HIF1A SNPs with clinical outcome of HCC patients.

SNP	Genotype	OS			RFS
SNP	Genotype	Death/total^a	HR^b (95% CI)	P-value^c	Recurrence/total^a	HR^a (95% CI)	P-value^b
rs2057482	CC	113/302	Ref.		187/302	Ref.
	CT	61/172	0.81(0.59–1.11)	0.192	96/172	0.74(0.58–0.95)	0.020
	TT	5/13	0.95(0.36–2.49)	0.914	9/13	1.09(0.54–2.17)	0.814
	Additive		0.85(0.64–1.13)	0.256		0.81(0.65–1.02)	0.070
	Dominant		0.82(0.60–1.12)	0.203		0.76(0.59–0.97)	0.028
	Recessive		1.05(0.41–2.72)	0.917		1.24(0.63–2.45)	0.537
rs1957757	CC	162/454	Ref.		273/454	Ref.
	CT	11/24	0.76(0.39–1.50)	0.433	13/24	0.70(0.38–1.29)	0.252
	TT	5/11	3.16(1.26–7.94)	0.014	8/11	1.75(0.86–3.59)	0.124
	Additive		1.24(0.81–1.91)	0.315		1.07(0.77–1.50)	0.675
	Dominant		1.07(0.61–1.87)	0.819	21/35	0.95(0.59–1.52)	0.815
	Recessive		3.17(1.26–7.97)	0.014		1.77(0.86–3.62)	0.120
rs2301113	AA	70/188	Ref.		117/188	Ref.
	AC	84/228	0.88(0.64–1.22)	0.444	138/228	0.89(0.70–1.14)	0.366
	CC	23/73	0.68(0.42–1.05)	0.120	38/73	0.71(0.49–1.03)	0.074
	Additive		0.84(0.67–1.05)	0.124		0.86(0.72–1.02)	0.076
	Dominant		0.83(0.61–1.13)	0.244	176/301	0.85(0.67–1.07)	0.172
	Recessive		0.73(0.46–1.15)	0.173		0.76(0.54–1.08)	0.120

Abbreviations: CI, confidence interval; HR, hazard ratio; Ref., reference.

^aDue to genotyping fail, sample size of individual SNPs may not add up to total.

^bAdjusted by gender, age, HBV, AFPlevel, stage, Differentiation, treatment.

^cSignificant P values (P < 0.05).