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. Author manuscript; available in PMC: 2015 Dec 25.
Published in final edited form as: Nat Commun. 2015 Jun 25;6:7518. doi: 10.1038/ncomms8518

Fig. 8. A model of PACS-2 regulation of ADAM17 and EGFR activity.

Fig. 8

The ADAM17 proform mainly resides in the secretory apparatus, and during its transit to the cell surface, furin-mediated cleavage generates the mature (active) form. We propose that PACS-2 controls ADAM17 cell-surface availability by diverting endocytosed ADAM17 away from degradative pathways and towards sustained ErbB ligand shedding and EGFR activation. PACS-2 is therefore an important regulator of auto- para-, and juxtacrine ErbB signalling in vivo.