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. Author manuscript; available in PMC: 2015 Dec 25.
Published in final edited form as: Nature. 2015 Jun 25;522(7557):492–496. doi: 10.1038/nature14513

Fig. 1. Spontaneous mitotic arrest upon bypass of senescence.

Fig. 1

a, Representative movie frames of a normal mitosis. Arrows, nuclear envelope break down and cytokinesis. Scale Bar, 10 µm. b, Mitotic duration of individual indicated cells (upper panel). Mean mitotic duration ± s.e.m. (lower panel) (Man-Whitney test, compared to IMR-90 E6E7 PD36). c, Growth curves of indicated IMR-90 derivatives. d, Mitotic duration of indicated derivatives as in b. Results were reproduced independently at least twice. e, f, Mitotic duration of IMR-90 E6E7 (e) or p53dd (f) cells expressing hTert as in b. Cells were infected at indicated PD. *P<0.05, **P<0.005, ***P<0.0001. Mann-Whitney test.