Table 2.
Top CpG methylation sites associated with body mass index in GOLDN (n=991), FHS (n=1,935 for batch 1 and 442 for batch 2), and ARIC (n=2,105) at the level of genome-wide significance (P<1.1×10−7) in the discovery phase.
| Marker | Chr | Gene | GOLDN | FHS Case-Control | FHS Random Sample | ARIC | Meta P | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| βa ± SE | P | β ± SE | P | β ± SE | P | β ± SE | P | ||||
| cg00574958 | 11 | CPT1A | −0.0009 ± 0.0001 | 7.6×10−11 | −0.04 ± 0.004 | 2.4×10−24 | −0.04 ± 0.01 | 1.2×10−5 | −0.003 ± 0.0007 | 7.2×10−6 | 3.5×10−37 |
| cg04332373 | 4 | CD38 | 0.0013 ± 0.0002 | 1.9×10−9 | 0.01 ± 0.004 | 0.004 | 0.002 ± 0.01 | 0.84 | 0.003 ± 0.0009 | 0.0009 | 3.7×10−11 |
| cg17287155 | 5 | AHRR | 0.0015 ± 0.0003 | 7.5×10−9 | 0.005 ± 0.004 | 0.22 | −0.006 ± 0.009 | 0.50 | 0.001 ± 0.0008 | 0.13 | 2.5×10−7 |
| cg26164488 | 2 | NA | 0.0012 ± 0.0002 | 4.9×10−8 | 0.005 ± 0.004 | 0.19 | −0.006 ± 0.009 | 0.55 | 0.005 ± 0.002 | 0.02 | 2.4×10−7 |
| cg07504977 | 10 | NA | 0.0011 ± 0.0002 | 5.0×10−8 | 0.02 ± 0.004 | 1.9×10−7 | 0.02 ± 0.01 | 0.04 | 0.004 ± 0.002 | 0.03 | 1.2×10−13 |
| cg14476101 | 1 | PHGDH | −0.0015 ± 0.0003 | 6.6×10−8 | −0.02 ± 0.004 | 1.7×10−8 | −0.03 ± 0.01 | 0.006 | −0.003 ± 0.001 | 0.05 | 4.7×10−15 |
| cg26680760 | 16 | NA | 0.0013 ± 0.0002 | 7.4×10−8 | 0.008 ± 0.004 | 0.06 | 0.008 ± 0.01 | 0.42 | −0.0006 ± 0.0009 | 0.51 | 1.7×10−6 |
| cg26140475 | 8 | NA | 0.001 ± 0.0002 | 1.0×10−7 | 0.003 ± 0.004 | 0.41 | −0.006 ± 0.009 | 0.51 | 0.002 ± 0.001 | 0.05 | 1.8×10−6 |
a
The β symbols in this table denote regression coefficients, not methylation scores