Table 3. Functional associations of discriminant proteins used to generate SOMs.
| 1 | 2 | 3 | 4 | 5 | 6 | 7 | 8 | |
|---|---|---|---|---|---|---|---|---|
| SOM | Fig 4A | Fig 5B | Fig 5A | Fig 7A and 7B | Fig 7A | Fig 7B | Fig 8 | Fig 9B |
| Classes compared | c-CS-s,m vs c-SC-s,m | c-SC-m vs c-SC-s | c-CS-m vs c-CS-s | t-CS-m vs t-SC-s,m | t-SC-m vs t-SC-s | t-CS-m vs t-CS-s | t-CS-s vs c-CS-s,m | t-SC-s vs t-SC-m, c-SC-s,m |
| Function | NL | MEM | MEM | RL | MEM | MEM | FL vs NL | |
| MAPK | BRAF | pCAMKII | PKCA | BRAF | BRAF | pRSK | ||
| pERK | pPKCAB | pERK | pPKCAB | pERK | pPKCAB | |||
| pPKCG | pMEK | pPKCG | pPKCG | |||||
| ELK | P38 | P38 | P38 | |||||
| MTOR | MTOR | pMTOR | MTOR | pMTOR | ||||
| S6 | pS6 | pS6 | S6, pS6 | S6 | S6, pS6 | |||
| pGSK3BS9 | AKT | AKT | RAPTOR | pGSK3BS9, T216 | ||||
| pP70S6 | pP70S6 | |||||||
| AD | CANA | CANA | CANA | |||||
| CDK5 | CDK5 | CDK5 | ||||||
| P3525 | P3525 | P3525 | ||||||
| ERBB4 | ERBB4 | TAU | TAU | |||||
| SNCA | SNCA | SNCA | ||||||
| IL1B | IL1B | |||||||
| nNOS | ||||||||
| NMDAR | pNR1 | pNR2A | pNR1 | pNR2A | ||||
| NR1 | NR2B | |||||||
| pNUMB | pNUMB | GLUR3 | GLUR3 | |||||
| HSA21 | DYRK1A | DYRK1A | DYRK1A | |||||
| ITSN1 | ITSN1 | |||||||
| SOD1 | SOD1 | SOD1 | RRP1 | |||||
| APP | APP | |||||||
| IEG | ARC | ARC | ARC | ARC | ||||
| EGR1 | EGR1 | EGR1 | ||||||
| Apoptosis | BCL2 | BAD | BAD | |||||
| Histone | H3AcK18 | H3AcK18 | H3AcK9 | |||||
| H3MeK4 | H3MeK4 | |||||||
| Misc | GFAP | SHH | GFAP | |||||
| UBC | UBC | UBC | UBC | UBC |
Figures illustrating each SOM and the classes compared in each are indicated. Where more than two classes were compared (columns 1, 4, 7 and 8), only those proteins common to all comparisons are listed; complete lists of proteins for each comparison are provided in S1 and S2 Tables. MAPK, components of the MAP kinase pathway; MTOR, components of the mechanistic target of rapamycin pathway; AD, proteins observed to be abnormal in brains from patients with or mouse models of Alzheimer’s Disease; NMDAR, subunits of ionotropic glutamate receptors and interacting proteins; Hsa21, proteins encoded by human chromosomes 21; IEG, immediate early gene proteins; apoptosis-related, BAD, proapoptotic, BCL2, antiapoptotic; histone, histone protein H3 modifications: Ac, acetylation, Me, methylation, K amino acid number of modified lysine residue; Misc, miscellaneous.