Table 6. SOM discriminating proteins are enriched in pathways relevant to neurological function.
| KEGG Pathway | # | RPPA components | % | # with RPPA PPI | % |
|---|---|---|---|---|---|
| mTOR signaling pathway | 61 | 17 | 28 | 43 | 70 |
| Long-term potentiation | 70 | 17 | 24 | 39 | 56 |
| ErbB signaling pathway | 88 | 18 | 20 | 63 | 72 |
| Alzheimer's disease | 50 | 8 | 16 | 29 | 58 |
| HIF-1 signaling pathway | 109 | 16 | 15 | 56 | 51 |
| Neurotrophin signaling pathway | 116 | 16 | 14 | 69 | 59 |
| Cholinergic synapse | 95 | 12 | 13 | 30 | 32 |
| Dopaminergic synapse | 124 | 14 | 11 | 49 | 40 |
| Glutamatergic synapse | 101 | 10 | 10 | 31 | 31 |
| Apoptosis | 86 | 7 | 8 | 44 | 51 |
| Serotonergic synapse | 87 | 7 | 8 | 21 | 24 |
| MAPK signaling pathway | 256 | 18 | 7 | 122 | 48 |
| Axon guidance | 118 | 6 | 5 | 33 | 28 |
Pathways were obtained from the Kyoto Encyclopedia of Genes and Genomes database http://www.kegg.jp/. Proteins listed in Table 3 were used to search the KEGG pathway database. #, total number of protein components in the pathway; RPPA component, %: number/% of proteins from Table 3 that are components of the pathway; # with RPPA PPI/%: number/% of pathway components that interact with one or more proteins from Table 3.