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. 2015 Apr 15;43(9):4627–4639. doi: 10.1093/nar/gkv275

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© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 5. — SSO treatment partially restores enzymatic activity of methionine synthase reductase (MTRR). Fibroblasts from a patient homozygous for the c.903+469T>C mutation were transfected with an SSO that target both ESEs (ESE-SSO) or a non-targeting sequence (Ctr). Fibroblasts were then labeled with [⁵⁷Co]cyanocabalamine and MTRR activity was determined indirectly by measuring methylcobalamine (MeCbl) synthesis (expressed as% of total labeled cobalamin derivatives). Adenosylcobalamine (AdoCbl) synthesis was measured as a control. The vertical lines represent the range of duplicate determinations in a representative experiment.