Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2015 Apr 8;43(9):4733–4745. doi: 10.1093/nar/gkv296

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com

PMC Copyright notice

Figure 1. — C-rich telomeric DNA from C. elegans and humans forms fundamentally different structures. LEFT: CD spectra of the DNA constructs based on human (A) and C. elegans (D) C-rich telomeric DNA repeats as a function of pH and the number of telomeric repeats. The spectra were acquired at 20°C. The insets show the pH-induced changes in the UV absorption spectra of the constructs. CENTRE: Imino regions of the 1D ¹H NMR spectra of the DNA constructs based on human (B) and C. elegans (E) C-rich telomeric DNA repeats as a function of pH and the number of telomeric repeats. The spectra were acquired at 20°C. Regions of the spectra typical of imino protons involved in C.C⁺, Watson-Crick (W-C) and Hoogsteen base-pairing are indicated. RIGHT: Non-denaturing PAGE of the DNA constructs based on human (C) and C. elegans (F) C-rich telomeric DNA repeats as a function of pH and the number of telomeric repeats.