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. 2015 Apr 13;43(9):4650–4660. doi: 10.1093/nar/gkv307

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© The Author(s) 2015. Published by Oxford University Press on behalf of Nucleic Acids Research.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 2. — Schematics of observed release event classes. After uptake by internalization (A), two alternative fates of labeled lipoplexes were observed: (i) Release into the cytosol (B) was followed by depletion from the cytosol (C), which was occasionally replenished by repeated release (D). After depletion, fluorescent siRNA was observed to accumulate in perinuclear structures (E). Occasionally, influx of intact siRNA into the nucleus was observed (F). (ii) Lipoplex siRNA lost integrity upon extensive dwelling in endosomal structures without release (G). The symbols given in the legend and the designation (A) through (G) will be maintained in all subsequent documentation.