Table A.1.

Abbreviations used in the text.

Abbreviation	Full text
ABE	average bioequivalence
AUC	area under the blood concentration-time curve
BE	bioequivalence
BIE	bioinequivalence
Cmax	peak concentration
CI	confidence interval
CV	coefficient of variation
EMA	European Medicines Agency
FDA	The United States Food and Drug Administration
GLL	generalized law of likelihood
GLR	generalized likelihood ratio
GMR	geometric mean ratio
HVD	highly variable drug
IBE	individual bioequivalence
LI	likelihood interval
MLE	maximum likelihood estimate
PBE	population bioequivalence
RSABE	reference scaled average bioequivalence
TOST	Two-One-Sided-Tests