Table 5. Relative risks (and 95% CIs) of colorectal cancer by quintile (Q) of glycemic load for each ethnic group (multivariate model 2 only)1.
| Cases | Q2 | Q3 | Q4 | Q5 | P for trend | |
|---|---|---|---|---|---|---|
| n | ||||||
| Men2 | ||||||
| African American | 166 | 1.06 (0.65, 1.75) | 1.31 (0.78, 2.21) | 1.18 (0.66, 2.09) | 1.29 (0.68, 2.44) | 0.404 |
| Japanese American | 491 | 1.11 (0.73, 1.69) | 1.13 (0.74, 1.73) | 0.92 (0.59, 1.44) | 0.95 (0.59, 1.53) | 0.399 |
| Latino | 172 | 0.83 (0.55, 1.24) | 1.00 (0.65, 1.54) | 1.06 (0.66, 1.71) | 1.17 (0.67, 2.03) | 0.456 |
| White | 259 | 0.91 (0.60, 1.38) | 1.02 (0.65, 1.62) | 1.77 (1.11, 2.80) | 1.69 (0.98, 2.92) | 0.006 |
| Women3 | ||||||
| African American | 300 | 1.02 (0.71, 1.47) | 1.05 (0.71, 1.56) | 0.93 (0.59, 1.46) | 0.74 (0.43, 1.29) | 0.507 |
| Japanese American | 335 | 1.00 (0.56, 1.79) | 1.25 (0.72, 2.18) | 0.82 (0.47, 1.46) | 0.76 (0.42, 1.37) | 0.050 |
| Latina | 168 | 0.96 (0.62, 1.50) | 0.84 (0.51, 138) | 0.48 (0.25, 0.93) | 0.75 (0.38, 1.46) | 0.107 |
| White | 216 | 1.00 (0.64, 1.56) | 1.05 (0.65, 1.68) | 1.18 (0.71, 1.98) | 0.68 (0.35, 1.33) | 0.594 |
Energy-adjusted glycemic load was determined by the residual method. Q2 through Q5 adjusted glycemic load values were 59.5 to <68.5, 68.5 to <76.3, 76.3 to <85.5, and ≥85.5, respectively, in men and 64.0 to <72.3, 72.3 to <79.5, 79.5 to <88.0, ≥88.0, respectively, in women. In the multivariate model 2, Cox regression models were adjusted for age, ethnicity, time since cohort entry, family history of colorectal cancer, history of colorectal polyp, pack-years of cigarette smoking, BMI, hours of vigorous activity, nonsteroidal anti-inflammatory drug use, multivitamin use, energy intake (logarithmically transformed), replacement hormone use (women only), and alcohol, red meat, folate, vitamin D, calcium, and dietary fiber intakes.
P for interaction = 0.009.
P for interaction = 0.579.