Figure 6.
(a) Structures of complexes studied. (b) Plot of relative hydrophobicity, as indicated by retention times on RP-HPLC, against cellular accumulation of iridium at IC50 concentrations in A2780 cells, after exposure to complexes 2, 4, 7, 8, and 11–14, showing a correlation of hydrophobicity with cellular accumulation. (c) Comparison of cellular accumulation of iridium and antiproliferative activity of complexes 2, 4, 7, 8, and 11–14 in A2780 cells, showing that in general higher cellular accumulation results in more potent complexes.