Table 2. Calculated TONs and TOFs for Complexes 2, 4, 11, and 12 for the Catalytic Oxidation of NADH to NAD⁺ Monitored via UV–Visible Spectroscopy at Various Concentrations of NADH (69, 103, and 146 μM) with a Fixed Complex Concentration of 2.5 μM over a 24 h Period in 0.5% MeOH/99.5% H₂O at 310 K in 5 mM Na₂HPO₄/NaH₂PO₄ Buffer, pH 7.5^a.

complex	NADH conc (μM)	TON (24 h)	TOF (h–1)b
[(η5-Cp*)Ir(2-(4′-fluorophenyl)pyridine)Cl], 2	69	11	0.6
	103	19	1.1
	146	22	1.2
[(η5-Cp*)Ir(2-phenyl-5-fluoropyridine)Cl], 4	69	13	0.7
	103	20	1.2
	146	22	1.1
[(η5-Cp*)Ir(2-(4′-hydroxyphenyl)pyridine)Cl], 11	69	14	1.9
	103	21	2.6
	146	28	3.2
[(η5-Cp*)Ir(2-phenyl-5-hydroxypyridine)Cl], 12	69	13	1.4
	103	15	1.8
	146	22	2.6

^aThe conversion of NADH to NAD⁺ was followed from the absorption at 339 nm.

^bTOFs were calculated as the gradient of time vs TON during the first 2 h of the reaction time.