Table 3. IC50 Vaules for Complexes 1–15 in A2780 Cells and Complexes 1, 2, 5, 6, 8, 10, 11, and 14 in HCT-116, MCF-7, and A549 Cellsa.
| IC50 values (μM) |
||||
|---|---|---|---|---|
| complex | A2780 | HCT-116 | MCF-7 | A549 |
| 1 | 4.5 ± 0.2 | 3.7 ± 0.3 | 9.6 ± 0.4 | 10.36 ± 0.07 |
| 2 | 2.7 ± 0.3 | 6.8 ± 0.1 | 4.8 ± 0.3 | 2.1 ± 0.3 |
| 3 | >50 | n.d. | n.d. | n.d. |
| 4 | >60 | n.d. | n.d. | n.d. |
| 5 | 6.9 ± 0.3 | 21.3 ± 0.7 | 11.6 ± 0.5 | 15.8 ± 0.4 |
| 6 | 4.4 ± 0.4 | 18.8 ± 0.5 | 6.5 ± 0.3 | 5.9 ± 0.1 |
| 7 | 24.73 ± 2.30 | n.d. | n.d. | n.d. |
| 8 | 2.7 ± 0.1 | 27.5 ± 0.9 | 11.4 ± 0.4 | 20.1 ± 0.3 |
| 9 | >50 | n.d. | n.d. | n.d. |
| 10 | 47 ± 1 | 57.3 ± 0.9 | 47 ± 2 | 89 ± 1 |
| 11 | 47.3 ± 0.1 | 29.3 ± 0.8 | 28.6 ± 0.9 | 56.67 ± 0.04 |
| 12 | 13.29 ± 0.88 | n.d. | n.d. | n.d. |
| 13 | 1.18 ± 0.08 | n.d. | n.d. | n.d. |
| 14 | 3.9 ± 0.2 | 9.6 ± 0.6 | 3.7 ± 0.1 | 8.7 ± 0.3 |
| 15 | 1.26 ± 0.01 | n.d. | n.d. | n.d. |
| 16b | 10.78 ± 1.72 | n.d. | n.d. | n.d. |
| 17b | 2.14 ± 0.50 | n.d. | n.d. | n.d. |
| cisplatin | 1.2 ± 0.2 | 5.2 ± 0.3 | 7.0 ± 0.1 | 3.5 ± 0.2 |
Drug exposure time was 24 h followed by a 72 h recovery time. All values were determined as independent duplicates of triplicate experiments, and the standard deviations were calculated.
From ref (4b).