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. 2015 Mar 25;34(11):2683–2694. doi: 10.1021/acs.organomet.5b00097

Table 3. IC50 Vaules for Complexes 115 in A2780 Cells and Complexes 1, 2, 5, 6, 8, 10, 11, and 14 in HCT-116, MCF-7, and A549 Cellsa.

  IC50 values (μM)
complex A2780 HCT-116 MCF-7 A549
1 4.5 ± 0.2 3.7 ± 0.3 9.6 ± 0.4 10.36 ± 0.07
2 2.7 ± 0.3 6.8 ± 0.1 4.8 ± 0.3 2.1 ± 0.3
3 >50 n.d. n.d. n.d.
4 >60 n.d. n.d. n.d.
5 6.9 ± 0.3 21.3 ± 0.7 11.6 ± 0.5 15.8 ± 0.4
6 4.4 ± 0.4 18.8 ± 0.5 6.5 ± 0.3 5.9 ± 0.1
7 24.73 ± 2.30 n.d. n.d. n.d.
8 2.7 ± 0.1 27.5 ± 0.9 11.4 ± 0.4 20.1 ± 0.3
9 >50 n.d. n.d. n.d.
10 47 ± 1 57.3 ± 0.9 47 ± 2 89 ± 1
11 47.3 ± 0.1 29.3 ± 0.8 28.6 ± 0.9 56.67 ± 0.04
12 13.29 ± 0.88 n.d. n.d. n.d.
13 1.18 ± 0.08 n.d. n.d. n.d.
14 3.9 ± 0.2 9.6 ± 0.6 3.7 ± 0.1 8.7 ± 0.3
15 1.26 ± 0.01 n.d. n.d. n.d.
16b 10.78 ± 1.72 n.d. n.d. n.d.
17b 2.14 ± 0.50 n.d. n.d. n.d.
cisplatin 1.2 ± 0.2 5.2 ± 0.3 7.0 ± 0.1 3.5 ± 0.2
a

Drug exposure time was 24 h followed by a 72 h recovery time. All values were determined as independent duplicates of triplicate experiments, and the standard deviations were calculated.

b

From ref (4b).