Table 1.

Characteristics of the three patients at baseline and during established continuous subcutaneous cortisol infusion. TDD, total daily dose; 3DD, three divided doses. Lab reference values: 0900–1200 h (200–500 nmol/l), 0000–0900 h (50–250 nmol)

Patient	Starting rate of hydrocortisone (mg/h)	Mean serum cortisol (nmol//l)	Adjusted rate of hydrocortisone (mg/h)	Subsequent mean serum cortisol (nmol/l)
Patient 1 (TDD 20 mg in 3DD)
0400–0900	1.1	–	1.1	–
0900–1400	0.9	430	0.9	357
1400–1800	0.8	385	0.8	272
1800–2200	0.6	344	0.6	251
2200–0400	0.7	–	0.6	–
Total over 24 h (mg)	19.8	–	19.2	–
Patient 2 (TDD 30 mg in 3DD)
0400–0900	1	–	1.3	–
0900–1400	0.7	–	1	–
1400–1800	0.6	–	0.9	–
1800–2200	0.4	–	0.7	–
2200–0400	0.5	–	0.8	–
Total over 24 h (mg)	15.5	–	23.6	–
Patient 3 (TDD 20 mg in 3DD)
0400–0900	1	–	1	–
0900–1400	0.7	400	0.8	–
1400–1800	0.6	292	0.7	–
1800–2200	0.4	163	0.5	–
2200–0400	0.5	91	0.6	–
Total over 24 h (mg)	15.5	–	17.4	–