Table 3.
Baseline characteristics by allele combination
| Characteristics | 0 risk allele | One risk allele | Two risk alleles | P-value* | p-value** |
|---|---|---|---|---|---|
| N | 707 | 143 | 9 | ||
| Gender, men n (%) | 166 (23.5) | 27 (18.8) | 2 (22.2) | 0.488 | 0.972 |
| Mean age, years (SD) | 53.2 (14.0) | 52.7 (10.0) | 54.3 (10.2) | 0.902 | 0.797 |
| Mean BMI, kg/m2 (SD) | 30.0 (7.5) | 30.0 (6.7) | 32.0 (6.9) | 0.722 | 0.420 |
| Mean WHR (SD) | 0.88 (0.10) | 0.89 (0.08) | 0.92 (0.11) | 0.484 | 0.266 |
| Mean SBP, mmHg (SD) | 123 (20) | 127 (23) | 121 (12) | 0.113 | 0.737 |
| Mean DBP, mmHg (SD) | 75 (12) | 77 (13) | 75 (12) | 0.117 | 0.884 |
| Hypertension, yes (%) | 466 (65.9) | 98 (68.5) | 8 (88.9) | 0.301 | 0.118 |
| Mean HbA1c, % (SD) | 6.2 (1.4) | 6.5 (1.7) | 6.6 (1.5) | 0.154 | 0.586 |
| Mean FBG, mmol/l (SD) | 6.3 (3.0) | 6.9 (3.6) | 7.0 (3.3) | 0.140 | 0.599 |
| Mean 2-h glucose, mmol/l (SD) | 7.4 (3.2) | 8.2 (4.7) | 9.0 (4.2) | 0.040 | 0.264 |
| Median urine creatinine, mmol/l (25th-75th percentiles) | 7.9 [5.2-11.8] | 7.9 [4.5-12.1] | 5.6 [5.5-8.8] | 0.664 | 0.466 |
| Median urine Microalbumin, mg/l (25th-75th percentiles) | 4.4 [3.0-11.4] | 4.3 [3.0-11.7] | 3.0 [3.0-7.3] | 0.537 | 0.293 |
| Median ACR, mg/mmol (25th-75th percentiles) | 0.75 [0.41-1.61] | 0.77 [0.41-1.50] | 0.54 [0.34-1.06] | 0.876 | 0.541 |
| Median serum creatinine,μmol/l (25th-75th percentiles) | 80 [69-92] | 79 [69-90] | 85 [82-92] | 0.254 | 0.244 |
| Median eGFR (MDRD), ml/min (SD) | 85.9 [70.8-102.2] | 84.2 [73.9-99.1] | 76.6 [73.6-81.0] | 0.258 | 0.147 |
| eGFR (MDRD) <60, n (%) | 67 (9.5) | 11 (7.7) | 1 (11.1) | 0.781 | 0.846 |
| Median eGFR (CKD-EPI), ml/min (SD) | 91.8 [72.0-109.9] | 91.2 [75.2-107.9] | 82.2 [77.1-85.2] | 0.275 | 0.160 |
| eGFR (CKD-EPI) <60, n (%) | 60 (8.5) | 12 (8.4) | 1 (11.1) | 0.960 | 0.786 |
ACR, urinary albumin/creatinine ratio; CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; eGFR, estimated glomerular filtration rate; MDRD, Modification of Diet in Renal Disease; SD, standard deviation
*p-values from chi square, ANOVA and Kruskal-Wallis tests
**p-values from recessive genetic models