Table 4.
Overall | |||
---|---|---|---|
Allele | Phenotype | Effects size (95 % CI) | P |
rs60910145 G/G | Serum creatinine (loge[μmol/l]) | 0.192 (-0.094 to 0.478) | 0.289 |
eGFR (MDRD) [ml/min] | −18.54 (-48.59 to 11.51) | 0.227 | |
eGFR (CKD-EPI) [ml/min] | −18.90 (-43.76 to 5.96) | 0.136 | |
Prevalent CKD (MDRD) | 23.47 (0.92 to 599.29) | 0.074 | |
Prevalent CKD (CKD-EPI) | 42.72 (1.22 to ∞) | 0.047 | |
Albumin/creatinine ratio (loge[mg/mmol]) | −1.02 (-2.62 to 0.57) | 0.210 | |
Systolic blood pressure (mmHg) | −0.36 (-27.67 to 26.74) | 0.979 | |
rs73885319 G/G | Serum creatinine (loge[μmol/l]) | 0.191 (-0.094 to 0.478) | 0.189 |
eGFR (MDRD) [ml/min] | −18.54 (-48.59 to 11.51) | 0.227 | |
eGFR (CKD-EPI) [ml/min] | −18.90 (-43.76 to 5.96) | 0.136 | |
Prevalent CKD (MDRD) | 23.47 (0.92 to 599.29) | 0.074 | |
Prevalent CKD (CKD-EPI) | 42.72 (1.22 to ∞) | 0.047 | |
Albumin/creatinine ratio (loge[mg/mmol]) | −1.02 (-2.62 to 0.57) | 0.210 | |
Systolic blood pressure (mmHg) | −0.36 (-27.67 to 26.94) | 0.979 | |
rs71785313 Del/Del | Serum creatinine (loge[μmol/l]) | 0.038 (-0.144 to 0.219) | 0.684 |
eGFR (MDRD) [ml/min] | −7.16 (-26.19 to 11.87) | 0.461 | |
eGFR (CKD-EPI) [ml/min] | −5.99 (-21.74 to 9.76) | 0.456 | |
Prevalent CKD (MDRD) | 0.0 | - | |
Prevalent CKD (CKD-EPI) | 0.0 | - | |
Albumin/creatinine ratio (loge[mg/mmol]) | −0.123 (-1.134 to 0.888) | 0.811 | |
Systolic blood pressure (mmHg) | −6.27 (-23.55 to 11.02) | 0.478 |
Models are adjusted for age, sex, diabetes status and hypertension
Effect estimates are mean difference and 95 % confidence intervals for quantitative traits and odds ratio and 95 % confidence intervals for qualitative traits
CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; eGFR, estimated glomerular filtration rate; MDRD, Modification of Diet in Renal Disease