Table 6.
Generalized linear and logistic regression models showing the effects of genes on kidney functions and other continuous predictors (additive model)
| Overall | |||
|---|---|---|---|
| Allele | Phenotype | Effects size (95%CI) | P |
| rs60910145 G | Serum creatinine (loge[μmol/l]) | −0.020 (-0.072 to 0.033) | 0.466 |
| eGFR (MDRD) [ml/min] | 1.26 (-4.27 to 6.79) | 0.656 | |
| eGFR (CKD-EPI) [ml/min] | 2.28 (-2.29 to 6.86) | 0.328 | |
| Prevalent CKD (MDRD) | 0.80 (0.28 to 2.27) | 0.665 | |
| Prevalent CKD (CKD-EPI) | 1.12 (0.39 to 3.16) | 0.836 | |
| Albumin/creatinine ratio (loge[mg/mmol]) | −0.178 (-0.504 to 0.147) | 0.283 | |
| Systolic blood pressure (mmHg) | −0.03 (-5.06 to 4.99) | 0.989 | |
| rs73885319 G | Serum creatinine (loge[μmol/l]) | −0.018 (-0.069 to 0.034) | 0.503 |
| eGFR (MDRD) [ml/min] | 0.99 (-4.42 to 6.40) | 0.720 | |
| eGFR (CKD-EPI) [ml/min] | 2.07 (-2.40 to 6.55) | 0.364 | |
| Prevalent CKD (MDRD) | 0.76 (0.27 to 2.16) | 0.601 | |
| Prevalent CKD (CKD-EPI) | 1.08 (0.38 to 3.03) | 0.887 | |
| Albumin/creatinine ratio (loge[mg/mmol]) | −0.126 (-0.446 to 0.195) | 0.442 | |
| Systolic blood pressure (mmHg) | −0.03 (-4.95 to 4.89) | 0.990 | |
| rs71785313 Del | Serum creatinine (loge[μmol/l]) | 0.019 (-0.022 to 0.060) | 0.367 |
| eGFR (MDRD) [ml/min] | −2.38 (-6.68 to 1.93) | 0.323 | |
| eGFR (CKD-EPI) [ml/min] | −2.91 (-6.46 to 0.65) | 0.110 | |
| Prevalent CKD (MDRD) | 0.86 (0.39 8to 1.93) | 0.712 | |
| Prevalent CKD (CKD-EPI) | 1.00 (0.42 to 2.34) | 0.993 | |
| Albumin/creatinine ratio (loge[mg/mmol]) | 0.035 (-0.207 to 0.277) | 0.777 | |
| Systolic blood pressure (mmHg) | 4.48 (0.58 to 8.38) | 0.025 | |
Models are adjusted for age, sex, diabetes status and hypertension
Effect estimates are mean difference and 95 % confidence intervals for quantitative traits and odds ratio and 95 % confidence intervals for qualitative traits. CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration; eGFR, estimated glomerular filtration rate; MDRD, Modification of Diet in Renal Disease