Mice were treated at 14 and 29 °C ambient temperatures Mice body temperatures were recorded 1 hr before the first MOD injection and at different intervals thereafter. Black filled arrows indicate the time of METH injection while grey filled arrows indicate the time of MOD injection. Data are presented as mean core temperature (°C) ± SEM (n = 5–10) at the indicated times from animals treated with VEH (white circle), MOD (grey circle, dotted line), METH (black inverted triangle), or M+M (dark grey inverted triangle, dotted line). Repeated measures two-way ANOVA followed by Fisher’s LSD. *: pˊ0.05 vs. VEH.