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. Author manuscript; available in PMC: 2015 Jun 26.
Published in final edited form as: Neurotox Res. 2014 Sep 27;27(1):71–83. doi: 10.1007/s12640-014-9493-9

Figure 2. Effects of modafinil (MOD) on METH-induced changes in striatal Tyrosine hydroxylase (TH) immunoreactivity evaluated at 14 and 29 °C ambient temperatures.

Figure 2

Representative images of the striatum from brains of animals treated with either VEH (A, E), MOD (B, F), METH (C, G) or M+M (D, H), scale bar: 100 µm, and their respective higher magnification photomicrographs (Aˊ–Hˊ), scale bar: 50 µm. Mice were euthanized 6 days after the last METH injection and brains were processed for TH immunoreactivity. Average integrated density (relative to VEH) was determined in a region of interest located/placed in the dorsolateral striatum. Values are expressed as mean ± SEM (n = 5–10). Two way ANOVA followed by Bonferroni. ***: p<0.001 vs. VEH-29°C; &&: p<0.01 and &&&: p<0.001 vs. METH-29°C.