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. Author manuscript; available in PMC: 2015 Jun 26.
Published in final edited form as: Neurotox Res. 2014 Sep 27;27(1):71–83. doi: 10.1007/s12640-014-9493-9

Figure 4. Effects of modafinil (MOD) on METH-induced changes in striatal astroglial activation evaluated at 14 and 29 °C ambient temperatures.

Figure 4

Representative images of the striatum from animals treated with either VEH (A, E), MOD (B, F), METH (C, G) or M+M (D, H), scale bar: 100 µm. Mice were euthanized 6 days after the last METH injection and brains were processed for GFAP immunoreactivity. The immunoreactive area was determined in a region of interest located in the dorsolateral striatum (relative to VEH). Values are expressed as mean ± SEM (n = 5–11). Two way ANOVA followed by Bonferroni. ***: p<0.001 vs. VEH of same ambient temperature; &&:& p<0.001 vs. METH of same ambient temperature.