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. 2015 May;6(5-6):184–213. doi: 10.18632/genesandcancer.65

Table 7. Ongoing clinical trials using HDACi for treatment of lymphoma, leukemia, and myeloma.

Trial title HDACi Combination target Phase
WEE1 Inhibitor MK-1775 and Belinostat in Treating Patients With Relapsed or Refractory Myeloid Malignancies or Untreated Acute Myeloid Leukemia Belinostat WEE1 I
Belinostat and Yttrium Y 90 Ibritumomab Tiuxetan in Patients W/Relapsed Aggressive B-Cell NHL Belinostat Radiotherapy II
Panobinostat and Everolimus in Treating Patients With Recurrent Multiple Myeloma, Non-Hodgkin Lymphoma, or Hodgkin Lymphoma Panobinostat mTOR I, II
Panobinostat in Treating Patients With Relapsed or Refractory Non-Hodgkin Lymphoma Panobinostat II
Romidepsin in Treating Patients With Lymphoma, Chronic Lymphocytic Leukemia, or Solid Tumors With Liver Dysfunction Romidepsin I
Alisertib and Romidepsin in Treating Patients With Relapsed or Refractory B-Cell or T-Cell Lymphomas Romidepsin Aurora Kinase I
Rituximab, Romidepsin, and Lenalidomide in Treating Patients With Recurrent or Refractory B-cell Non-Hodgkin Lymphoma Romidepsin CD20, immunomodulation, proliferation, angiogenesis I, II
Romidepsin and Lenalidomide in Treating Patients With Previously Untreated Peripheral T-Cell Lymphoma Romidepsin Immunomodulation, proliferation, angiogenesis II
Alisertib in Combination With Vorinostat in Treating Patients With Relapsed or Recurrent Hodgkin Lymphoma, B-Cell Non-Hodgkin Lymphoma, or Peripheral T-Cell Lymphoma Vorinostat Aurora Kinase I
Vorinostat and Combination Chemotherapy With Rituximab in Treating Patients With HIV-Related Diffuse Large B-Cell Non-Hodgkin Lymphoma or Other Aggressive B-Cell Lymphomas Vorinostat CD20 I, II
Bortezomib and Vorinostat as Maintenance Therapy After Autologous Stem Cell Transplant in Treating Patients With Non-Hodgkin Lymphoma Vorinostat Proteosome II
Cytarabine and Daunorubicin Hydrochloride or Idarubicin and Cytarabine With or Without Vorinostat in Treating Younger Patients With Previously Untreated Acute Myeloid Leukemia Vorinostat DNA synthesis, Topoisomerase II III