Figure 3. MAPK pathway is involved in resveratrol-induced Egr-1 expression.

A. Cells were treated with or without 100 μM of resveratrol for 6 h after pretreatment with indicated inhibitors for 1 h, and Egr-1 protein level were examined by western blotting. B. Cells were exposed to 100 μM of resveratrol for 6 h after transfected with either Elk-1 siRNA or Luciferase siRNA. C. The summary of ERK/JNK-Elk-1-Egr-1 pathway: resveratrol sequentially activates MAPK cascade, Elk-1 and Egr-1.