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. 2015 Jun 27;13:203. doi: 10.1186/s12967-015-0563-4

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© Koh et al. 2015

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Changes in glomerular phenotypes in anthocyanin-treated db/db mice. Glomerular mesangial fractional area, TGF-β₁ expression, and collagen IV expression in the cortical area of db/m and db/db mice, with or without anthocyanin treatment, were evaluated. a–l Representative sections stained with periodic acid-Schiff reagent and representative immunohistochemical staining for TGF-β1 and type IV collagen (original magnification ×400). m–o Quantitative analyses of the mesangial fractional area (%) (m), TGF-β1 (fold) (n), and type IV collagen (fold) (o). **p < 0.01 vs. db/m control, db/m ATC, and db/db ATC mice. Col IV type IV collagen, PAS periodic acid-Schiff stain.