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. 2015 Jun 25;11(6):e1005334. doi: 10.1371/journal.pgen.1005334

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© 2015 Lin, Wagner

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 4 — (A) Kaplan-Meier plots demonstrate overall survival between esophageal carcinoma (ESCA) patients classified by chronological age (red: older than mean age of all patients; blue: younger). (B) Alternatively, the datasets were classified by epigenetic age-predictions (Horvath-predictor, red: older than mean age-predictions of all patients; blue: younger). Younger epigenetic age-predictions were associated with poorer prognosis—even thought this was not observed with regard to chronological age. In analogy, DNAm profiles of (C) thyroid carcinoma (THCA) and (D) renal clear cell carcinoma (KIRC) were stratified by mean age-predictions and in these tumors younger epigenetic age-predictions were associated with better prognosis.