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. 2015 May 14;26(6):975–986. doi: 10.1021/acs.bioconjchem.5b00191

Figure 6.

Figure 6

PET imaging of 4T1 tumor-bearing mice with novel HaloTag ligands. (A) Chemical structure of NOTA-HTL2G-S and NOTA-HTL2G-L, with different lengths of PEG. (B) PET imaging of mice with two 4T1 xenografts; the left tumor does not express HaloTag protein, and the right tumor expresses HaloTag protein. Mice were injected with the short (64Cu-NOTA-HTL2G-S) or long (64Cu-NOTA-HTL2G-L) form of the HaloTag ligand. In addition, a blocking agent was used with 64Cu-NOTA-HTL2G-L. Accumulation of 64Cu-NOTA-HTL2G-L ligand can be seen in HaloTag tumors from 3 to 24 h postinjection. Reprinted with permission from ref (120). Copyright 2013 AJTR.